The DNA of ancient viruses first spotted in the Neanderthal genome have now been identified in modern humans – although whether they cause disease is not yet clear.
In 2010, researchers unveiled the genomes of two extinct groups of human – the Neanderthals and the Denisovans. This revealed that some humans share a few per cent of their DNA with their extinct cousins. Ever since, geneticists have been poring over the ancient DNA sequences for an insight into Stone Age life.
Last year, Jack Lenz’s team at the Albert Einstein College of Medicine in New York began looking for signs of endogenous retroviruses in the ancient genomes, a class of virus that not only invades cells but worms its way into DNA. These retroviral gene sequences make up about 8 per cent of the human genome, and are part of what is sometimes called “junk” or non-coding DNA because they don’t contain genetic instructions to make proteins.
Lenz found 14 retroviral gene sequences in the Neanderthal and Denisovan DNA. When he compared this to the human genome used as a standard reference, he found that none of the sequences overlapped – in other words, it seemed that modern humans did not share this endogenous retroviral DNA with their extinct cousins.
Not so fast
That was until Robert Belshaw at Plymouth University, UK, and Gkikas Magiorkinis at the University of Oxford, who study whether these viral DNA sequences contribute to disease, decided to take a closer look.
They examined the genomes of 67 people with cancer, and found they each contained seven of the sequences supposedly unique to the ancient humans. Belshaw suspects that all 14 might still be around, although finding the rest will take more time. The viruses insert themselves into DNA repeats – patterns that occur in multiple locations throughout the genome, only one of which will carry the sequence in question, so tracking them down is time consuming.
The finding suggests that the viruses probably infected our ancestors before we split from the lineage that led to Neanderthals and Denisovans, roughly 400,000 years ago.
So why did Lenz’s team miss the retroviral sequences in humans?
Stone-tipped spears predate existence of humans by 85,000 years
Remains of the world’s oldest known stone-tipped throwing spears, described in a new paper, and so ancient that they actually predate the earliest known fossils for our species by 85,000 years.
There are a few possible implications, and both are mind-blowing. The first is that our species could be much older than previously thought, which would forever change the existing human family tree.
The second, and more likely at this point, is that a predecessor species to ours was extremely crafty and clever, making sophisticated tools long before Homo sapiens emerged.
Homo heidelbergensis, aka Heidelberg Man, lived in Africa, Europe and western Asia from at least 600,000 years ago. He clearly got around, and many think this species was the direct ancestor ofHomo sapiens in Africa and Neanderthals in Europe and Asia
(Reuters) – Humans first made dogs their best friends in prehistoric Europe, where groups of hunter-gathers learnt to tame dangerous wolves into companions between 19,000 and 32,000 years ago, scientists said on Thursday.
The new research, based on analysis of DNA fragments from fossils of ancient wolves and dogs, confounds earlier theories that dogs were originally domesticated in the Middle East or East Asia.
Experts generally agree that dog training started out with a few grey wolves hanging around human encampments in the hope of picking up scraps. Over time, humans accepted them, perhaps initially as guards or hunting partners, and taught them to be useful companions.
Where and when this happened, however, has been a matter of controversy.
Now Olaf Thalmann, from Finland’s University of Turku, and colleagues believe they have placed initial doggy taming firmly in Europe after finding that modern dogs’ DNA most closely matches that of either ancient European canines or modern European wolves, but not wolves outside Europe.
“We’re pretty sure that Europe played a major role in the domestication of the dog,” Thalmann, whose research was published on Thursday in the journal Science, said in an interview.
Ancient DNA helps researchers unlock secrets of a cave bear and horse which roamed Earth hundreds of thousands of years ago.
SANTA FE—Where did the first Americans come from? Most researchers agree that Paleoamericans moved across the Bering Land Bridge from Asia sometime before 15,000 years ago, suggesting roots in East Asia. But just where the source populations arose has long been a mystery.
Now comes a surprising twist, from the complete nuclear genome of a Siberian boy who died 24,000 years ago—the oldest complete genome of a modern human sequenced to date. His DNA shows close ties to those of today’s Native Americans. Yet he apparently descended not from East Asians, but from people who had lived in Europe or western Asia. The finding suggests that about a third of the ancestry of today’s Native Americans can be traced to “western Eurasia,” with the other two-thirds coming from eastern Asia, according to a talk at a meeting* here by ancient DNA expert Eske Willerslev of the University of Copenhagen. It also implies that traces of European ancestry previously detected in modern Native Americans do not come solely from mixing with European colonists, as most scientists had assumed, but have much deeper roots.
I’m still processing that Native Americans are one-third European,” says geneticist Connie Mulligan of the University of Florida in Gainesville. “It’s jaw-dropping.” At the very least, says geneticist Dennis O’Rourke of the University of Utah in Salt Lake City, “this is going to stimulate a lot of discussion.” Researchers have been trying to parse the origins of the first Americans for decades. Most agree that people moved across Beringia, via a vast ice age land bridge (see map p. 410), and began spreading through the Americas, reaching Chile by 14,500 years ago. But the origins of the source populations are not clear, and some archaeologists have even suggested that ancient Europeans crossing the Atlantic were part of the mix (Science, 16 March 2012, p. 1289). Others have contended that early skeletons found in the Americas, such as the 9000-year-old Kennewick Man, show some European features (Science, 10 April 1998, p. 190). In his talk, Willerslev argued that the ancient genome “can actually explain a lot of these inconsistencies,” by offering glimpses of prehistoric populations before more recent migrations and other demograp
Oct. 17, 2013 at 2:33 PM ET
Georgian National Museum
An oddball skull from a site in the former Soviet republic of Georgia has sparked a debate over early human evolution.
Putting together the pieces of a 1.8 million-year-old skull from the former Soviet republic of Georgia has led researchers to a surprising conclusion: Specimens that supposedly represent several early human species might be merely different-sized individuals from the same species.
If the conclusion holds up, the skull discovery would require a major rewrite for the story of early human evolution. Such species as Homo habilis and Homo rudolfensis, long a part of humanity’s “bushy” family tree, could be folded into a wide-ranging species known as Homo erectus.
“It is really an extraordinary find in many respects,” Christoph Zollikofer of Zurich’s Anthropological Institute and Museum, one of the researchers behind the study published in this week’s issue of the journal Science, told reporters during a teleconference.
The key to the claim is the assembly of a fossil called Skull 5. The specimen was discovered in separate pieces at a sprawling excavation in Dmanisi, about 50 miles (80 kilometers) from Tbilisi, Georgia’s capital. Over the past eight years, Skull 5′s jaw and the cranium were painstakingly matched up and compared with four other hominid skulls unearthed at the site.
C. Zollikofer and M. S. Ponce de Leon / Univ. of Zurich
This graphic shows the five skulls found at the Dmanisi dig, numbered 1 through 5.
Professor Bryan Sykes: “Yeti hairs genetically identical to polar bear”
Research by a British scientist has concluded that the legendary Himalayan yeti may in fact be a sub-species of brown bear.
DNA tests on hair samples carried out by Oxford University genetics professor Bryan Sykes found that they matched those from an ancient polar bear.
He subjected the hairs to the most advanced tests available.
He says the most likely explanation for the myth is that the animal is a hybrid of polar bears and brown bears.
Prof Sykes told the BBC that there may be a real biological animal behind the yeti myth.
“I think this bear, which nobody has seen alive,… may still be there and may have quite a lot of polar bear in it,” he said.
“It may be some sort of hybrid and if its behaviour is different from normal bears, which is what eyewitnesses report, then I think that may well be the source of the mystery and the source of the legend.
Bigfoot is real, and there’s now both DNA and video evidence to prove it, claims one group of devoted Sasquatch researchers.
The group’s “never-before-seen footage” of an alleged Bigfoot creature sleeping in the woods of Kentucky has been presented this week along with various blood and hair samples said to be unlike anything seen before.
The group’s startling statements are supposedly backed by 11 outside laboratories and universities, which all reviewed the findings, and which were provided with blind samples, according to the report by the Sasquatch Genome Project.
“We want people to understand that this is a serious study,” Dr. Melba Ketchum, a genetics scientist, who led the project during the course of the five-year study, told CBS DFW.
Unsurprisingly, others are challenging Ketchum’s credibility, including New York University whose laboratory Ketchum claims similarly tested a field sample and found it having usual human mitochondrial results.
In 2001, scientists announced an amazing discovery: the oldest skull of a human ancestor ever found. The 3½ million year old fossil was remarkably complete, and unlike any previous fossil find. Its discovery – by a team led by Meave Leakey of the famous Leakey fossil-hunting family – has revolutionised our understanding of how humans evolved.
The great mystery of our evolution is how an ape could have evolved into the extraordinary creature that is a human being. There has never been another animal like us on the planet. And yet ten million years ago there was no sign that humans would take over the world. Instead the Earth was dominated by the apes. More than 50 different species of ape roamed the world – ten million years ago Earth really was the planet of the apes. Three million years later, most had vanished. In their place came something clearly related to the apes, but also completely different: human beings!
Big pharma can’t allow cancer or any other disease to be cured because they will lose their business of drugs, pills and all the illness causing products they make and distribute to the dis-eased. Plus the elite need people to be sick and die to depopulate the world. Curing cancer has no benefit to them whatsoever even though the cure has been made and known for decades. Medicinal herbs and other forms of plants are known to be beneficial in eliminating cancer.