Posts Tagged ‘cancer sequencing’

Supreme Court to hear fight over taking DNA from arrested people

WASHINGTON — On a cold February night three years ago, police in suburban Arlington, Va., received a frantic call. A young woman said her roommate had been abducted at gunpoint by a short, clean-shaven man who sped away in a silver SUV.

At dawn, a motorist spotted the victim in a snowy field near a highway, raped and strangled, but alive. An alert officer, hearing the lookout report, recalled that he’d jotted down the license tag of a silver Dodge Durango whose driver lurked near bars at midnight, leading to the quick arrest of a short, clean-shaven Marine named Jorge Torrez.

Ten years ago, Virginia became the first state to require, upon arrest for a serious crime, a mouth swab for DNA. The sample from Torrez, sent to a state crime lab and entered into the FBI‘s DNA database, confirmed he was the rapist. A few weeks later a DNA match also led to charges against him in the rape and murder of two girls, ages 8 and 9, in Zion, Ill., where Torrez had gone to high school. Jerry Hobbs, the father of one of the girls, had been in prison for the crimes.

This month, the U.S. Supreme Court will take up a privacy rights challenge to taking DNA from people who are arrested. The case could either end the practice or make it the norm nationwide.

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Be the first to comment - What do you think?  Posted by admin - February 4, 2013 at 2:36 am

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DNA map offers hope on cancer treatments

Cancer will become a manageable disease rather than a death sentence thanks to a revolutionary treatment which will be available within five years, British specialists predict.Out of control: biologists still cannot explain why cancerous cells will proliferate and spread to other organs if unchecked

All patients will soon have their tumour’s DNA, its genetic code, sequenced, enabling doctors to ensure they give exactly the right drugs to keep the disease at bay.

Doctors hope it will be an important step towards transforming some types of cancer into a chronic rather than fatal disease.

The technique could enable terminally ill patients, who can currently expect to live only months, to carry on for a decade or more in relatively good health, according to specialists at the Institute of Cancer Research in London.

“We should be aspiring to cure cancer, but for people with advanced disease, it will be a question of managing them better so they survive for much longer – for many years,” said Prof Alan Ashworth, chief executive of the institute.

“Cancer often appears in people who are old, and if we can keep them alive long enough for them to die of something else, then we are turning cancer into a chronic disease.”

Prof Ashworth said that understanding of how different cancers were caused by different genetic triggers was building “incredibly rapidly”.

Genetic profiling of tumours is already used to some extent, but current methods only look for a few genes. Women with advanced breast cancer are tested to see if their tumours have a particular variant of the HER2 gene, which causes a fifth of cases. Those with it are given Herceptin, but the same drug would do no good for those without the gene variant.

Advanced melanoma patients with a particular gene mutation are prescribed Vemurafenib, a pill that has been shown to increase survival, on average, from 9.6 to 13.2 months, and help patients feel much more energetic.

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Be the first to comment - What do you think?  Posted by admin - January 28, 2013 at 11:41 pm

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Researchers Claim To Have Sequenced Bigfoot DNA

A genetic researcher is saying that Bigfoot DNA assessments establish that the furry creature actually does exist. Dr. Melba S. Ketchum states she and her staff sequenced about three complete Sasquatch nuclear genomes and concluded the species is a human hybrid — a mosaic of human and novel non-human aspects. Their conclusions have still to go peer evaluation.

A Texas veterinarian says she and fellow genetic scientists have verified the existence of “Bigfoot,”even however their findings have even so to pass peer overview.

Dr. Melba S. Ketchum of Nacogdoches, founder of DNA Diagnostics Inc. in the eastern Texas town of Timpson, said she and her crew expended 5 several years on their research of purported Bigfoot hair and determined they have validated the existence of a hominin hybrid Pertinent Answers/Firms species, the famous creature frequently acknowledged as “Bigfoot” or “Sasquatch,” residing in North The usa.

There have been recurrent-but-unsubstantiated claims of Bigfoot sightings additional than the a long time, which include some grainy film clips.

In a release posted on the company’s Web internet site Saturday, the scientists say their DNA sequencing suggests the animal is a human relative that created about 15,000 several years back as a hybrid cross of present day Homo sapiens with an not known primate species.

Ketchum mentioned her team has sequenced three whole Sasquatch nuclear genomes and concluded the species is a human hybrid.

“Our examine has sequenced 20 comprehensive mitochondrial genomes and utilized up coming generation sequencing to obtain a few whole nuclear genomes from purported Sasquatch samples,” she claimed in the release. “The genome sequencing shows that Sasquatch mtDNA is identical to present day working day Homo sapiens, but Sasquatch nuDNA is a novel, mysterious hominin suitable to Homo sapiens and other primate species.

“Our facts Associated Items/Firms point out that the North American Sasquatch is a hybrid species, the final result of males of an unknown hominin species crossing with female Homo sapiens.”

Genetic testing has by now dominated out Homo neanderthalis and the Denisova hominin as contributors to Sasquatch mtDNA or nuDNA, she talked about.

“The male progenitor that contributed the not known sequence to this hybrid is special as its DNA is additional distantly removed from humans than other these days identified hominins like the Denisovan particular person,” Ketchum said.

“Sasquatch nuclear DNA is extremely novel and not at all what we experienced anticipated. Even although it has human nuclear DNA inside its genome, there are also distinctly non-human, non-archaic hominin, and non-ape sequences. We identify it as a mosaic of human and novel non-human sequence.”

She mentioned even far more take a look at is vital to “outstanding characterize and have an understanding of Sasquatch nuclear DNA.”

Ketchum, who describes herself as a veterinarian with 27 numerous a long time realistic experience in genetics investigation, which include forensics, needs general public officers and law enforcement to realize the Sasquatch as an indigenous folks today.

“Genetically, the Sasquatch are a human hybrid with unambiguously modern-day-day human maternal ancestry,” she mentioned. “Government at all quantities have to understand them as an indigenous men and women today and right absent guard their human and constitutional rights in the direction of men and women who would see in their bodily and cultural distinctions a ‘license’ to hunt, entice or get rid of them.”

Be the first to comment - What do you think?  Posted by admin - December 2, 2012 at 6:55 pm

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Bigfoot Does Exist, Claim Scientists

  • DNA tests show “Yeti” hair close to humans
  • But is it all an elaborate hoax?

 

DNA tests on hair found supposedly found in a Siberian may actually prove the existence of the Abominable Snowman. 

Three separate DNA tests of the hair reported it “came from a human-like creature which is not a Homosapien yet is more closely related to man than a monkey”.

Yeti hunters claim Yeti DNA is less than one per cent different to that of a human. But no-one has confirmed that “fact” to date, because no Yeti has ever been found or tested for DNA.

Until now. The DNA tests were carried out at universities in Moscow, St Petersburg at Idaho in the US. It is understood a fourth DNA test is also being carried out in the UK.

What do you think? Is it real? Or just a huge hoax? Tell us below.

“We had ten samples of hair to study, and have concluded that they belong to mammal, but not a human, and not the animals known to the area where they were found, like a bear, or wolf, or goat, or any other animal,” Professor Valentin Sapunov of the Russian State Hydrometeorological Institute said.

“It was a branch of our university in St Petersburg that carried out a DNA test, and the Zoological Institute of Russian Academy of Sciences. The tests were performed by laboratory of electronic microscopy and laboratory of molecular genealogical classification.”

The “Yeti hair” was allegedly found in Siberia’s Azasskaya Cave by Dr Igor Birtsev, Russia’s leading advocate of the existence of the abominable snowman.

But is it all an elaborate hoax? That’s the suggestion the Siberian Times is making this morning after Dr Birtsev strangely played down the findings.

“I doubt that they have indeed managed to carry out a DNA test on Azasskaya Cave hair, and doubt that they found how close the Yeti is to humans by its DNA,” he was quoted as saying.

“It has not been done anywhere in the world. I take it that they’ve worked with electronic microscopes, but have they compared it to other samples? I am not sure. So I am rather sceptical about Valentin Sapunov’s conclusions.”

Could it maybe have something to do with the fact that a major bookmaker is offering 100-1 odds on the existence of a yeti being proven by the end of 2012?

A Paddy Power spokesperson said: “It’s true, at odds of 100/1 we do risk putting a Bigfoot in our mouth if these recent sightings turn out to be genuine.”

And then there’s the fact that the “evidence” just happened to be released on Halloween. Real or not real? You tell us.

Be the first to comment - What do you think?  Posted by admin - November 27, 2012 at 12:56 am

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What is the Human Genome

Here is the definition taken from the Human Genome Project, “A genome is the complete collection of an organism’s genetic material. The human genome is ”"composed of about 20,000 to 25,000 genes located on the 23 pairs of chromosomes in a human cell.

A single human chromosome may contain more than 250 million DNA base pairs, and scientists estimate that the entire human genome consists of about 3 billion base pairs.

In the past eighteen months, scientists discovered more than 100 genetic variations that affect older people, such as: type 2 diabetes, asthma, Alzheimer’s disease, osteoporosis, high blood pressure and heart disease.

Genetic science is moving so fast that people now in their 60′s-80′s will see medical innovations that will touch their lives.

Francis Collins, MD, a leader in the Project, was astounded to see the huge amount of information derived from the genome, particularly in regards to older people.

As an example he cited age-related Macular degeneration, an eye disease troubling almost 2 million, visually impaired Americans. “Using new genomic tools we’ve discovered two genes that account for about 60% of the risk- the rest is smoking. But we were surprised. These genes are involved in inflammation, and everybody was thinking macular degeneration was caused by aging in the back of the eye.”

Macular degeneration tests are now being made using anti-inflammatory drugs, a complete change in the way it was formerly viewed.

Many scientists believe that the Human Genome Project has the potential to revolutionize both therapeutic and preventive medicine by providing insights into the basic biochemical processes that underlie many human diseases.

Be the first to comment - What do you think?  Posted by admin - November 5, 2012 at 4:17 pm

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Complete Genomics

It was once thought that the human genome would never be completely mapped out because it was much too complex. The human genome project found that, while complex, human genomes are not as complex as some very undistinguished creatures such as the roundworm and fruit fly.

Nevertheless the breakthrough was enormous and caused an incredible stir among scientists and researchers worldwide, opening doors to research about humans that had never before been seen.

At the center of the breakthrough was Complete Genomics, a California research facility that caused the stir when it announced in 2009 that it had sequenced its first human genome.  When they had finished it they submitted the data to the National Center for Biotechnology Information and scientists the world over clamored to see it.

Today Complete Genomics is a full-service life-sciences company. The DNA sequencing platform that they developed is used by researchers around the globe to analyze and sequence human genomes using their proprietary and data management software and their informatics.

When a researcher anywhere in the world needs a genome to be sequenced they send it to Complete Genomics for analysis in Mountain View, California. After sequencing the assembled sequences and variant reports are published and sent back to the various researchers who order them.

The proprietary software that Complete Genomics uses is adjusted for the study of human DNA exclusively, and they can provide researchers with genome variation files and also assembled sequences.

Today there are various research papers that have been submitted using the results found at Complete Genomics.  For example, their research was responsible for finding which gene was responsible for Miller Syndrome, a rare craniofacial disorder that had struck 1 member of a family of four.

It’s an amazing time to be alive, to be sure, and Complete Genomics is at the forefront of amazing changes that will soon be taking place that only years ago were hard to even imagine. Their technology will ultimately allow researchers to help find and, possibly, cure many diseases that afflict mankind.

1 comment - What do you think?  Posted by admin - at 4:16 pm

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